007/s13197-011-0343-yORIGINAL ARTICLEEffect of mixture of dietary fish protein and fish oil on lipid metabolism in ratsRyota Hosomi Kenji Fukunaga Hirofumi Arai Seiji Kanda Toshimasa Nishiyama Munehiro YoshidaRevised: 31 January 2011 / Accepted: 13 March 2011 / Published on-line: 30 March 2011 # Association of Meals Scientists Technologists (India)Abstract This study examined the effects of fish protein in combination with fish oil on rat lipid metabolism. Male Wistar rats had been divided into four groups and fed an AIN93G-based diet program with casein (20 ) + soybean oil (7 ), casein (10 ) + fish protein (ten ) + soybean oil (7 ), casein (20 ) + soybean oil (5 ) + fish oil (two ), and casein (ten ) + fish protein (10 ) + soybean oil (five ) + fish oil (2 ) for four weeks. The dietary combination of fish protein and fish oil decreased the contents of serum triacylglycerol, serum cholesterol, liver triacylglycerol and liver cholesterol as well as altering liver lipid fatty acid composition. These effects are partly because of the increase in fecal cholesterol, bile acid excretion, and enhanced enzyme activities of fatty acid -oxidation in the liver.Diethyl (aminomethyl)phosphonate Chemscene These information recommend that combined intake of fish protein and fish oil bring about both hypocholesterolemic and hypotriglyceridemic in serum plus the liver, while sole intake of fish protein or fish oil lower only cholesterol and triglyceride levels, respectively.Boc-amido-PEG9-amine web These results suggest that combined intake of fish protein and fish oil might play effective roles in theprevention of lifestyle-related illnesses as compared with sole fish protein intake.PMID:36628218 Search phrases Fish protein . Fish oil . n-3 polyunsaturated fatty acid . Lipid metabolismIntroduction In created countries, there is certainly an improved incidence of lifestyle-related ailments, including coronary heart disease (CHD), hyperlipidemia, atherosclerosis, diabetes, and hypertension. Epidemiological and experimental reports have shown the connection among diet plan as well as the incidence of CHD (Osler et al. 2002; Pereira et al. 2004). Dietary therapy is the first-choice treatment for CHD and is thought of to become as important as health-related remedy. Dietary proteins have also been identified to influence lipid metabolism in human subjects and animals (Sugano et al. 1990; Zhang and Beynen 1993; Wergedahl et al. 2004; Brandsch et al. 2006; Shukla et al. 2006; Hosomi et al. 2009). Most research have focused on the effects of plant protein compared with those of casein (Sugano et al. 1990). Hence, it can be usually assumed that the effects of dietary animal proteins are like these of dietary casein, even though dietary animal protein also impacts lipid metabolism (Zhang and Beynen 1993; Wergedahl et al. 2004; Brandsch et al. 2006; Shukla et al. 2006; Hosomi et al. 2009). Fish protein, which can be a significant macronuterient in fish, plays a vital part in human nutrition worldwide. Fish protein has been used as a primary ingredient in processed seafood, for example kamaboko and fish sausage, in Japan. Some researchers have recommended that fish protein diets decrease plasma cholesterol levels in laboratory animals as compared with those of a caseinR. Hosomi : K. Fukunaga (*) : M. Yoshida Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564?680, Japan e-mail: [email protected] H. Arai Division of Biotechnology and Environmental Chemistry, Kitami Institute of Technologies, Kitami, Hokkaido 090?507, Japan S. Kanda : T. N.